منابع مشابه
Glycolipids and benzylammonium lipids as novel antisepsis agents: synthesis and biological characterization.
New glycolipids and a benzylammonium lipid were rationally designed by varying the chemical structure of a D-glucose-derived hit compound active as lipid A antagonist. We report the synthesis of these compounds, their in vitro activity as lipid A antagonists on HEK cells, and the capacity to inhibit LPS-induced septic shock in vivo. The lack of toxicity and the good in vivo activity suggest the...
متن کاملBacterial glycolipids.
INTRODUCTION............................................................. 365 ISOLATION AND PURIFICATION................................... 365 CHEMISTRY OF GLYCOLIPIDS................................... 366 Glycosyl Diglycerides................................... 366 Acylated Sugar Derivatives................................................... 369 BIOSYNTHESIS.....................................
متن کاملPerformance of human immunostimulating agents in the improvement of fish cytogenetic preparations.
Inoculation with bacterial or fungal antigens that stimulate cell proliferation has been widely used to obtain metaphases for cytogenetic studies of fish. We evaluated the potential of new pharmaceutical compounds as mitogenic agents in fish, testing the efficacy of Aminovac (mixed antigens and epsilon-acetamidocaproic acid), Broncho-Vaxom (bacterial lysate) and Estimoral (bacterial lysate) to ...
متن کاملNovel Glycolipids Synthesized Using Plant Essential Oils and Their Application in Quorum Sensing Inhibition and as Antibiofilm Agents
Essential oils (EOs) form an important part of traditional medicine so their anti-microbial and, in the recent past, antiquorum sensing activity has been well studied. However it is likely that due to their hydrophobic nature and reduced solubility in aqueous environments full potential of their activity cannot be realized. hence it is only rational to formulate a process to make these molecule...
متن کاملNovel Levofloxacin Derivatives as Potent Antibacterial Agents
In this report, a new series of fluoroquinolone agents which was derived from levofloxacin was synthesized and evaluated against Gram-positive (Bacillus subtillis, Staphylococcus aureus, Staphylococcus epidermidis and Micrococcus luteus) and Gram-negative (Esherichio coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Serratia marcescens) organisms. The results showed that some of the synth...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry
سال: 2008
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2007.10.026